TY - JOUR
KW - ADME
KW - Drug development
KW - organ-on-chip
KW - Pharmacokinetics
AU - Marit Keuper-Navis
AU - Markus Walles
AU - Birk Poller
AU - Adam Myszczyszyn
AU - Thomas K. van der Made
AU - Joanne Donkers
AU - Hossein Eslami Amirabadi
AU - Martijn J. Wilmer
AU - Saskia Aan
AU - Bart Spee
AU - Rosalinde Masereeuw
AU - Evita van de Steeg
AB - Organ-on-chip (OoC) technology has led to in vitro models with many new possibilities compared to conventional in vitro and in vivo models. In this review, the potential of OoC models to improve the prediction of human oral bioavailability and intrinsic clearance is discussed, with a focus on the functionality of the models and the application in current drug development practice. Multi-OoC models demonstrating the application for pharmacokinetic (PK) studies are summarized and existing challenges are identified. Physiological parameters for a minimal viable platform of a multi-OoC model to study PK are provided, together with PK specific read-outs and recommendations for relevant reference compounds to validate the model. Finally, the translation to in vivo PK profiles is discussed, which will be required to routinely apply OoC models during drug development.
BT - Pharmacological Research
DA - 2023-09-01
DO - 10.1016/j.phrs.2023.106853
N2 - Organ-on-chip (OoC) technology has led to in vitro models with many new possibilities compared to conventional in vitro and in vivo models. In this review, the potential of OoC models to improve the prediction of human oral bioavailability and intrinsic clearance is discussed, with a focus on the functionality of the models and the application in current drug development practice. Multi-OoC models demonstrating the application for pharmacokinetic (PK) studies are summarized and existing challenges are identified. Physiological parameters for a minimal viable platform of a multi-OoC model to study PK are provided, together with PK specific read-outs and recommendations for relevant reference compounds to validate the model. Finally, the translation to in vivo PK profiles is discussed, which will be required to routinely apply OoC models during drug development.
PY - 2023
EP - 106853
T2 - Pharmacological Research
TI - The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development
UR - https://www.sciencedirect.com/science/article/pii/S1043661823002098
VL - 195
Y2 - 2023-10-30
SN - 1043-6618
ER -