TY - JOUR
KW - Angiogenesis
KW - CD4 T cell
KW - disease model
KW - endothelial cell
KW - in vitro models
KW - Macrophage
KW - microfluidic
KW - Neutrophil
AU - Justin Silberman
AU - Aakanksha Jha
AU - Holly Ryan
AU - Talia Abbate
AU - Erika Moore
AB - The advancement of in vitro techniques enables a better understanding of biological processes and improves drug screening platforms. In vitro studies allow for enhanced observation of cell behavior, control over the mimicked microenvironment, and the ability to use human cells. In particular, advances in vascular microenvironment recapitulation are of interest given vasculature influence in cardiovascular vascular diseases and cancer. These investigate alterations in endothelial cell behavior and immune cell interactions with endothelial cells. Specific immune cells such as monocytes, macrophages, neutrophils, and T cells influence endothelial cell behavior by promoting or inhibiting vasculogenesis through cell-cell interaction or soluble signaling. Results from these studies showcase cell behavior in vascular diseases and in the context of tumor metastasis. In this review, we discuss examples of in vitro studies modeling immune cell-endothelial cell interactions to present methods and recent findings in the field.
BT - Drug Delivery and Translational Research
DA - 2021-12-01
DO - 10.1007/s13346-021-00970-1
IS - 6
LA - en
N2 - The advancement of in vitro techniques enables a better understanding of biological processes and improves drug screening platforms. In vitro studies allow for enhanced observation of cell behavior, control over the mimicked microenvironment, and the ability to use human cells. In particular, advances in vascular microenvironment recapitulation are of interest given vasculature influence in cardiovascular vascular diseases and cancer. These investigate alterations in endothelial cell behavior and immune cell interactions with endothelial cells. Specific immune cells such as monocytes, macrophages, neutrophils, and T cells influence endothelial cell behavior by promoting or inhibiting vasculogenesis through cell-cell interaction or soluble signaling. Results from these studies showcase cell behavior in vascular diseases and in the context of tumor metastasis. In this review, we discuss examples of in vitro studies modeling immune cell-endothelial cell interactions to present methods and recent findings in the field.
PY - 2021
SP - 2482
EP - 2495
ST - Modeled vascular microenvironments
T2 - Drug Delivery and Translational Research
TI - Modeled vascular microenvironments: immune-endothelial cell interactions in vitro
UR - https://doi.org/10.1007/s13346-021-00970-1
VL - 11
Y2 - 2023-10-12
SN - 2190-3948
ER -