TY - JOUR
KW - 2D and 3D  models
KW - Disease biomarker discovery
KW - Drug development
KW - Microglia-targeted therapeutics
KW - Monocyte-derived microglia
KW - Neurodegenerative Diseases
AU - Carla Cuní-López
AU - Romal Stewart
AU - Anthony R. White
AU - Hazel Quek
AB - Microglia have an increasingly well-recognised role in the pathogenesis of neurodegenerative diseases, thereby becoming attractive therapeutic targets. However, the development of microglia-targeted therapeutics for neurodegeneration has had limited success. This stems partly from the lack of clinically relevant microglia model systems. To circumvent this translational gap, patient-derived microglial cell models established using conventional 2D in vitro techniques have emerged. Though promising, these models lack the microenvironment and multicellular interactions of the brain needed to maintain microglial homeostasis. In this review, we discuss the use of 3D in vitro platforms to improve microglia modelling and their potential benefits to fast-track drug development for neurodegenerative diseases.
BT - Journal of Neuroimmunology
DA - 2023-02-15
DO - 10.1016/j.jneuroim.2023.578017
N2 - Microglia have an increasingly well-recognised role in the pathogenesis of neurodegenerative diseases, thereby becoming attractive therapeutic targets. However, the development of microglia-targeted therapeutics for neurodegeneration has had limited success. This stems partly from the lack of clinically relevant microglia model systems. To circumvent this translational gap, patient-derived microglial cell models established using conventional 2D in vitro techniques have emerged. Though promising, these models lack the microenvironment and multicellular interactions of the brain needed to maintain microglial homeostasis. In this review, we discuss the use of 3D in vitro platforms to improve microglia modelling and their potential benefits to fast-track drug development for neurodegenerative diseases.
PY - 2023
EP - 578017
ST - 3D in vitro modelling of human patient microglia
T2 - Journal of Neuroimmunology
TI - 3D in vitro modelling of human patient microglia: A focus on clinical translation and drug development in neurodegenerative diseases
UR - https://www.sciencedirect.com/science/article/pii/S0165572823000036
VL - 375
Y2 - 2023-09-15
SN - 0165-5728
ER -