TY - JOUR
AU - Juan M. Fernández-Costa
AU - Ainoa Tejedera-Vilafranca
AU - Xiomara Fernández-Garibay
AU - Javier Ramón-Azcón
AB - Muscular dystrophies are a heterogeneous group of highly debilitating diseases that result in muscle atrophy and weakness. The lack of suitable cellular and animal models that reproduce specific aspects of their pathophysiology is one of the reasons why there are no curative treatments for these disorders. This highlights a considerable gap between current laboratory models and clinical practice. We strongly believe that organs-on-chip could help to fill this gap. Organs-on-chip, and in particular muscles-on-chip, are microfluidic devices that integrate functional skeletal muscle tissues. Biosensors in these systems allow monitoring of muscle homeostasis or drug responses in situ. This Perspective outlines the potential of organs-on-chip as advanced models for muscular dystrophies, as well as the current challenges and future opportunities for this technology.
BT - Disease Models & Mechanisms
DA - 2023-06-23
DO - 10.1242/dmm.050107
IS - 6
N2 - Muscular dystrophies are a heterogeneous group of highly debilitating diseases that result in muscle atrophy and weakness. The lack of suitable cellular and animal models that reproduce specific aspects of their pathophysiology is one of the reasons why there are no curative treatments for these disorders. This highlights a considerable gap between current laboratory models and clinical practice. We strongly believe that organs-on-chip could help to fill this gap. Organs-on-chip, and in particular muscles-on-chip, are microfluidic devices that integrate functional skeletal muscle tissues. Biosensors in these systems allow monitoring of muscle homeostasis or drug responses in situ. This Perspective outlines the potential of organs-on-chip as advanced models for muscular dystrophies, as well as the current challenges and future opportunities for this technology.
PY - 2023
EP - dmm050107
ST - Muscle-on-a-chip devices
T2 - Disease Models & Mechanisms
TI - Muscle-on-a-chip devices: a new era for in vitro modelling of muscular dystrophies
UR - https://doi.org/10.1242/dmm.050107
VL - 16
Y2 - 2023-09-15
SN - 1754-8403
ER -