TY - JOUR
AU - Hanna Vuorenpää
AU - Miina Björninen
AU - Hannu Välimäki
AU - Antti Ahola
AU - Mart Kroon
AU - Laura Honkamäki
AU - Jussi T. Koivumäki
AU - Mari Pekkanen-Mattila
AB - Microphysiological systems (MPS) are drawing increasing interest from academia and from biomedical industry due to their improved capability to capture human physiology. MPS offer an advanced in vitro platform that can be used to study human organ and tissue level functions in health and in diseased states more accurately than traditional single cell cultures or even animal models. Key features in MPS include microenvironmental control and monitoring as well as high biological complexity of the target tissue. To reach these qualities, cross-disciplinary collaboration from multiple fields of science is required to build MPS. Here, we review different areas of expertise and describe essential building blocks of heart MPS including relevant cardiac cell types, supporting matrix, mechanical stimulation, functional measurements, and computational modelling. The review presents current methods in cardiac MPS and provides insights for future MPS development with improved recapitulation of human physiology.
BT - Frontiers in Physiology
DA - 2023-7-06
DO - 10.3389/fphys.2023.1213959
N2 - Microphysiological systems (MPS) are drawing increasing interest from academia and from biomedical industry due to their improved capability to capture human physiology. MPS offer an advanced in vitro platform that can be used to study human organ and tissue level functions in health and in diseased states more accurately than traditional single cell cultures or even animal models. Key features in MPS include microenvironmental control and monitoring as well as high biological complexity of the target tissue. To reach these qualities, cross-disciplinary collaboration from multiple fields of science is required to build MPS. Here, we review different areas of expertise and describe essential building blocks of heart MPS including relevant cardiac cell types, supporting matrix, mechanical stimulation, functional measurements, and computational modelling. The review presents current methods in cardiac MPS and provides insights for future MPS development with improved recapitulation of human physiology.
PY - 2023
EP - 1213959
T2 - Frontiers in Physiology
TI - Building blocks of microphysiological system to model physiology and pathophysiology of human heart
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358860/
VL - 14
Y2 - 2023-09-15
SN - 1664-042X
ER -