TY - JOUR
KW - disease model
KW - Diseases
KW - Drug Discovery
KW - Lab-on-a-chip
KW - Toxicology
AU - Eric W. Esch
AU - Anthony Bahinski
AU - Dongeun Huh
AB - Microengineered cell culture systems are becoming sufficiently sophisticated that they can recapitulate many of the phenomena observed in tissues and organisms. Here, Huh and colleagues discuss the advances made in these 'organs-on-chips' and how they could be used in drug development, including target identification and validation, toxicity screening and stratified medicine.
BT - Nature Reviews Drug Discovery
DA - 2015-04
DO - 10.1038/nrd4539
IS - 4
LA - en
N2 - Microengineered cell culture systems are becoming sufficiently sophisticated that they can recapitulate many of the phenomena observed in tissues and organisms. Here, Huh and colleagues discuss the advances made in these 'organs-on-chips' and how they could be used in drug development, including target identification and validation, toxicity screening and stratified medicine.
PY - 2015
SP - 248
EP - 260
T2 - Nature Reviews Drug Discovery
TI - Organs-on-chips at the frontiers of drug discovery
UR - https://www.nature.com/articles/nrd4539
VL - 14
Y2 - 2023-08-29
SN - 1474-1784
ER -