TY - JOUR
KW - Cell Culture Techniques
KW - Humans
KW - Lab-On-A-Chip Devices
KW - organoids
AU - Sunghee Estelle Park
AU - Andrei Georgescu
AU - Dongeun Huh
AB - Recent studies have demonstrated an array of stem cell-derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for the production, control, and analysis of organoids and their microenvironment. In this Review, we explore organ-on-a-chip technology as a platform to fulfill this need and examine how this technology may be leveraged to address major technical challenges in organoid research. We also discuss emerging opportunities and future obstacles for the development and application of organoid-on-a-chip technology.
BT - Science (New York, N.Y.)
DA - 2019-06-07
DO - 10.1126/science.aaw7894
IS - 6444
LA - eng
N2 - Recent studies have demonstrated an array of stem cell-derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for the production, control, and analysis of organoids and their microenvironment. In this Review, we explore organ-on-a-chip technology as a platform to fulfill this need and examine how this technology may be leveraged to address major technical challenges in organoid research. We also discuss emerging opportunities and future obstacles for the development and application of organoid-on-a-chip technology.
PY - 2019
SP - 960
EP - 965
T2 - Science (New York, N.Y.)
TI - Organoids-on-a-chip
VL - 364
SN - 1095-9203
ER -