TY - JOUR
KW - Animals
KW - Blood-Brain Barrier
KW - Drug development
KW - Humans
KW - Lab-On-A-Chip Devices
KW - Neoplasms
KW - Organ Specificity
KW - Tissue engineering
KW - disease modeling
KW - Drug development
KW - human physiology
KW - human stem cells
KW - microfluidics
KW - Precision Medicine
KW - preclinical studies
KW - Tissue engineering
AU - Kacey Ronaldson-Bouchard
AU - Gordana Vunjak-Novakovic
AB - Organs-on-a-chip (OOCs) are miniature tissues and organs grown in vitro that enable modeling of human physiology and disease. The technology has emerged from converging advances in tissue engineering, semiconductor fabrication, and human cell sourcing. Encompassing innovations in human stem cell technology, OOCs offer a promising approach to emulate human patho/physiology in vitro, and address limitations of current cell and animal models. Here, we review the design considerations for single and multi-organ OOCs, discuss remaining challenges, and highlight the potential impact of OOCs as a fast-track opportunity for tissue engineering to advance drug development and precision medicine.
BT - Cell Stem Cell
DA - 2018-03-01
DO - 10.1016/j.stem.2018.02.011
IS - 3
LA - eng
N2 - Organs-on-a-chip (OOCs) are miniature tissues and organs grown in vitro that enable modeling of human physiology and disease. The technology has emerged from converging advances in tissue engineering, semiconductor fabrication, and human cell sourcing. Encompassing innovations in human stem cell technology, OOCs offer a promising approach to emulate human patho/physiology in vitro, and address limitations of current cell and animal models. Here, we review the design considerations for single and multi-organ OOCs, discuss remaining challenges, and highlight the potential impact of OOCs as a fast-track opportunity for tissue engineering to advance drug development and precision medicine.
PY - 2018
SP - 310
EP - 324
ST - Organs-on-a-Chip
T2 - Cell Stem Cell
TI - Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development
VL - 22
SN - 1875-9777
ER -