TY - JOUR
KW - Animals
KW - Humans
KW - microfluidics
KW - Organ Culture Techniques
KW - Virology
KW - Virus Diseases
KW - Virus Physiological Phenomena
KW - Viruses
KW - microfluidics
KW - microphysiological system
KW - organ-on-a-chip
KW - viral infections
KW - virus
AU - Huaqi Tang
AU - Yasmine Abouleila
AU - Longlong Si
AU - Ana Maria Ortega-Prieto
AU - Christine L. Mummery
AU - Donald E. Ingber
AU - Alireza Mashaghi
AB - While conventional in vitro culture systems and animal models have been used to study the pathogenesis of viral infections and to facilitate development of vaccines and therapeutics for viral diseases, models that can accurately recapitulate human responses to infection are still lacking. Human organ-on-a-chip (Organ Chip) microfluidic culture devices that recapitulate tissue-tissue interfaces, fluid flows, mechanical cues, and organ-level physiology have been developed to narrow the gap between in vitro experimental models and human pathophysiology. Here, we describe how recent developments in Organ Chips have enabled re-creation of complex pathophysiological features of human viral infections in vitro.
BT - Trends in Microbiology
DA - 2020-11
DO - 10.1016/j.tim.2020.06.005
IS - 11
LA - eng
N2 - While conventional in vitro culture systems and animal models have been used to study the pathogenesis of viral infections and to facilitate development of vaccines and therapeutics for viral diseases, models that can accurately recapitulate human responses to infection are still lacking. Human organ-on-a-chip (Organ Chip) microfluidic culture devices that recapitulate tissue-tissue interfaces, fluid flows, mechanical cues, and organ-level physiology have been developed to narrow the gap between in vitro experimental models and human pathophysiology. Here, we describe how recent developments in Organ Chips have enabled re-creation of complex pathophysiological features of human viral infections in vitro.
PY - 2020
SP - 934
EP - 946
T2 - Trends in Microbiology
TI - Human Organs-on-Chips for Virology
VL - 28
SN - 1878-4380
ER -