TY - JOUR
KW - induced pluripotent stem cells
KW - SARS-CoV-2
KW - Stem-cell biotechnology
AU - Kevin G. Chen
AU - Kyeyoon Park
AU - Jason R. Spence
AB - Clinical management of patients with severe complications of COVID-19 has been hindered by a lack of effective drugs and a failure to capture the extensive heterogeneity of the disease with conventional methods. Here we review the emerging roles of complex organoids in the study of SARS-CoV-2 infection, modelling of COVID-19 disease pathology and in drug, antibody and vaccine development. We discuss opportunities for COVID-19 research and remaining challenges in the application of organoids.
BT - Nature Cell Biology
DA - 2021-08
DO - 10.1038/s41556-021-00721-x
IS - 8
LA - en
N2 - Clinical management of patients with severe complications of COVID-19 has been hindered by a lack of effective drugs and a failure to capture the extensive heterogeneity of the disease with conventional methods. Here we review the emerging roles of complex organoids in the study of SARS-CoV-2 infection, modelling of COVID-19 disease pathology and in drug, antibody and vaccine development. We discuss opportunities for COVID-19 research and remaining challenges in the application of organoids.
PY - 2021
SP - 822
EP - 833
T2 - Nature Cell Biology
TI - Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids
UR - https://www.nature.com/articles/s41556-021-00721-x
VL - 23
Y2 - 2023-08-09
SN - 1476-4679
ER -