TY - JOUR
KW - ACE2
KW - COVID-19
KW - SARS-CoV
KW - antiviral
KW - combination therapy
AU - Christopher Hopkins
AU - Chidinma Onweni
AU - Victoria Zambito
AU - DeLisa Fairweather
AU - Kathryn McCormick
AU - Hideki Ebihara
AU - Thomas Caulfield
AU - Yu Shrike Zhang
AU - W. David Freeman
AB - The COVID-19 pandemic entered its third and most intense to date wave of infections in November 2020. This perspective article describes how combination therapies (polytherapeutics) are a needed focus for helping battle the severity of complications from SARS-CoV-2 infection. It outlines the types of systems that are needed for fast and efficient combinatorial assessment of therapeutic candidates. Proposed are micro-physiological systems using human iPSC as a format for tissue-specific modeling of infection, the use of gene-humanized zebrafish and C. elegans for combinatorial drug screens due to the animals being addressable in liquid multi-well formats, and the use of engineered pseudo-typing systems to safely model infection in the transgenic animals and engineered tissue systems.
BT - Journal of Molecular Biology
DA - 2021-05-14
DO - 10.1016/j.jmb.2021.166945
IS - 10
LA - en
N2 - The COVID-19 pandemic entered its third and most intense to date wave of infections in November 2020. This perspective article describes how combination therapies (polytherapeutics) are a needed focus for helping battle the severity of complications from SARS-CoV-2 infection. It outlines the types of systems that are needed for fast and efficient combinatorial assessment of therapeutic candidates. Proposed are micro-physiological systems using human iPSC as a format for tissue-specific modeling of infection, the use of gene-humanized zebrafish and C. elegans for combinatorial drug screens due to the animals being addressable in liquid multi-well formats, and the use of engineered pseudo-typing systems to safely model infection in the transgenic animals and engineered tissue systems.
PY - 2021
EP - 166945
T2 - Journal of Molecular Biology
TI - Platforms for Personalized Polytherapeutics Discovery in COVID-19
UR - https://www.sciencedirect.com/science/article/pii/S0022283621001467
VL - 433
Y2 - 2023-08-09
SN - 0022-2836
ER -