TY - JOUR
AU - Jenna M. Kastenschmidt
AU - Suhas Sureshchandra
AU - Aarti Jain
AU - Jenny E. Hernandez-Davies
AU - Rafael De Assis
AU - Zachary W. Wagoner
AU - Andrew M. Sorn
AU - Mahina Tabassum Mitul
AU - Aviv I. Benchorin
AU - Elizabeth Levendosky
AU - Gurpreet Ahuja
AU - Qiu Zhong
AU - Douglas Trask
AU - Jacob Boeckmann
AU - Rie Nakajima
AU - Algimantas Jasinskas
AU - Naresha Saligrama
AU - D. Huw Davies
AU - Lisa E. Wagar
AB - Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To advance informed vaccine design, it is critical that we understand the cellular dynamics underlying responses to different antigen formats. Here, we sought to understand how antigen-specific B and T cells were activated and participated in adaptive immune responses within the mucosal site. Using a human tonsil organoid model, we tracked the differentiation and kinetics of the adaptive immune response to influenza vaccine and virus modalities. Each antigen format elicited distinct B and T cell responses, including differences in their magnitude, diversity, phenotype, function, and breadth. These differences culminated in substantial changes in the corresponding antibody response. A major source of antigen format-related variability was the ability to recruit naive vs. memory B and T cells to the response. These findings have important implications for vaccine design and the generation of protective immune responses in the upper respiratory tract.
BT - Immunity
DA - 7/2023
DO - 10.1016/j.immuni.2023.06.019
LA - en
N2 - Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To advance informed vaccine design, it is critical that we understand the cellular dynamics underlying responses to different antigen formats. Here, we sought to understand how antigen-specific B and T cells were activated and participated in adaptive immune responses within the mucosal site. Using a human tonsil organoid model, we tracked the differentiation and kinetics of the adaptive immune response to influenza vaccine and virus modalities. Each antigen format elicited distinct B and T cell responses, including differences in their magnitude, diversity, phenotype, function, and breadth. These differences culminated in substantial changes in the corresponding antibody response. A major source of antigen format-related variability was the ability to recruit naive vs. memory B and T cells to the response. These findings have important implications for vaccine design and the generation of protective immune responses in the upper respiratory tract.
PY - 7
EP - S1074761323002765
T2 - Immunity
TI - Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids
UR - https://linkinghub.elsevier.com/retrieve/pii/S1074761323002765
Y2 - 2023-08-07
SN - 10747613
ER -