TY - JOUR
AU - Yago Juste-Lanas
AU - Silvia Hervas-Raluy
AU - José Manuel García-Aznar
AU - Alejandra González-Loyola
AB - Many different strategies can be found in the literature to model organ physiology, tissue functionality, and disease in vitro; however, most of these models lack the physiological fluid dynamics present in vivo. Here, we highlight the importance of fluid flow for tissue homeostasis, specifically in vessels, other lumen structures, and interstitium, to point out the need of perfusion in current 3D in vitro models. Importantly, the advantages and limitations of the different current experimental fluid-flow setups are discussed. Finally, we shed light on current challenges and future focus of fluid flow models applied to the newest bioengineering state-of-the-art platforms, such as organoids and organ-on-a-chip, as the most sophisticated and physiological preclinical platforms.
BT - APL Bioengineering
DA - 2023-08-04
DO - 10.1063/5.0146000
IS - 3
N2 - Many different strategies can be found in the literature to model organ physiology, tissue functionality, and disease in vitro; however, most of these models lack the physiological fluid dynamics present in vivo. Here, we highlight the importance of fluid flow for tissue homeostasis, specifically in vessels, other lumen structures, and interstitium, to point out the need of perfusion in current 3D in vitro models. Importantly, the advantages and limitations of the different current experimental fluid-flow setups are discussed. Finally, we shed light on current challenges and future focus of fluid flow models applied to the newest bioengineering state-of-the-art platforms, such as organoids and organ-on-a-chip, as the most sophisticated and physiological preclinical platforms.
PY - 2023
EP - 031501
T2 - APL Bioengineering
TI - Fluid flow to mimic organ function in 3D in vitro models
UR - https://doi.org/10.1063/5.0146000
VL - 7
Y2 - 2023-08-07
SN - 2473-2877
ER -