TY - JOUR
KW - Humans
KW - Immunotherapy
KW - Models, Immunological
KW - Neoplasms
KW - organoids
KW - Precision Medicine
KW - Tumor Microenvironment
KW - Immunotherapy
KW - organoids
KW - Tumor Microenvironment
AU - Kanako Yuki
AU - Ning Cheng
AU - Michitaka Nakano
AU - Calvin J. Kuo
AB - Cellular interactions in the tumor microenvironment (TME) significantly govern cancer progression and drug response. The efficacy of clinical immunotherapies has fostered an exponential interest in the tumor immune microenvironment, which in turn has engendered a pressing need for robust experimental systems modeling patient-specific tumor-immune interactions. Traditional 2D in vitro tumor immunotherapy models have reconstituted immortalized cancer cell lines with immune components, often from peripheral blood. However, newly developed 3D in vitro organoid culture methods now allow the routine culture of primary human tumor biopsies and increasingly incorporate immune components. Here, we present a viewpoint on recent advances, and propose translational applications of tumor organoids for immuno-oncology research, immunotherapy modeling, and precision medicine.
BT - Trends in Immunology
DA - 2020-08
DO - 10.1016/j.it.2020.06.010
IS - 8
LA - eng
N2 - Cellular interactions in the tumor microenvironment (TME) significantly govern cancer progression and drug response. The efficacy of clinical immunotherapies has fostered an exponential interest in the tumor immune microenvironment, which in turn has engendered a pressing need for robust experimental systems modeling patient-specific tumor-immune interactions. Traditional 2D in vitro tumor immunotherapy models have reconstituted immortalized cancer cell lines with immune components, often from peripheral blood. However, newly developed 3D in vitro organoid culture methods now allow the routine culture of primary human tumor biopsies and increasingly incorporate immune components. Here, we present a viewpoint on recent advances, and propose translational applications of tumor organoids for immuno-oncology research, immunotherapy modeling, and precision medicine.
PY - 2020
SP - 652
EP - 664
T2 - Trends in Immunology
TI - Organoid Models of Tumor Immunology
VL - 41
SN - 1471-4981
ER -