TY - JOUR
KW - Adult
KW - Adult Stem Cells
KW - Cell biology
KW - Cell- and Tissue-Based Therapy
KW - disease
KW - Humans
KW - organoids
KW - Pluripotent Stem Cells
KW - Regenerative Medicine
KW - adult stem cell
KW - biobank
KW - model system
KW - organoids
KW - Personalized medicine
AU - Frans Schutgens
AU - Hans Clevers
AB - Organoids are in vitro-cultured three-dimensional structures that recapitulate key aspects of in vivo organs. They can be established from pluripotent stem cells and from adult stem cells, the latter being the subject of this review. Organoids derived from adult stem cells exploit the tissue regeneration process that is driven by these cells, and they can be established directly from the healthy or diseased epithelium of many organs. Organoids are amenable to any experimental approach that has been developed for cell lines. Applications in experimental biology involve the modeling of tissue physiology and disease, including malignant, hereditary, and infectious diseases. Biobanks of patient-derived tumor organoids are used in drug development research, and they hold promise for developing personalized and regenerative medicine. In this review, we discuss the applications of adult stem cell-derived organoids in the laboratory and the clinic.
BT - Annual Review of Pathology
DA - 2020-01-24
DO - 10.1146/annurev-pathmechdis-012419-032611
LA - eng
N2 - Organoids are in vitro-cultured three-dimensional structures that recapitulate key aspects of in vivo organs. They can be established from pluripotent stem cells and from adult stem cells, the latter being the subject of this review. Organoids derived from adult stem cells exploit the tissue regeneration process that is driven by these cells, and they can be established directly from the healthy or diseased epithelium of many organs. Organoids are amenable to any experimental approach that has been developed for cell lines. Applications in experimental biology involve the modeling of tissue physiology and disease, including malignant, hereditary, and infectious diseases. Biobanks of patient-derived tumor organoids are used in drug development research, and they hold promise for developing personalized and regenerative medicine. In this review, we discuss the applications of adult stem cell-derived organoids in the laboratory and the clinic.
PY - 2020
SP - 211
EP - 234
ST - Human Organoids
T2 - Annual Review of Pathology
TI - Human Organoids: Tools for Understanding Biology and Treating Diseases
VL - 15
SN - 1553-4014
ER -