TY - JOUR
KW - Allergy and Immunology
KW - Biomedical Research
KW - Cell Differentiation
KW - Epithelial Cells
KW - Epithelium
KW - Fetal Development
KW - Homeostasis
KW - Humans
KW - Infections
KW - Lymphopoiesis
KW - organoids
KW - Regeneration
KW - T-Lymphocytes
KW - Thymus Gland
KW - Tumor Microenvironment
AU - Yotam E. Bar-Ephraim
AU - Kai Kretzschmar
AU - Hans Clevers
AB - Much of our knowledge regarding the interactions between epithelial tissues and the immune system has been gathered from animal models and co-cultures with cell lines. However, unique features of human cells cannot be modelled in mice, and cell lines are often transformed or genetically immortalized. Organoid technology has emerged as a powerful tool to maintain epithelial cells in a near-native state. In this Review, we discuss how organoids are being used in immunological research to understand the role of epithelial cell-immune cell interactions in tissue development and homeostasis, as well as in diseases such as cancer.
BT - Nature Reviews. Immunology
DA - 2020-05
DO - 10.1038/s41577-019-0248-y
IS - 5
LA - eng
N2 - Much of our knowledge regarding the interactions between epithelial tissues and the immune system has been gathered from animal models and co-cultures with cell lines. However, unique features of human cells cannot be modelled in mice, and cell lines are often transformed or genetically immortalized. Organoid technology has emerged as a powerful tool to maintain epithelial cells in a near-native state. In this Review, we discuss how organoids are being used in immunological research to understand the role of epithelial cell-immune cell interactions in tissue development and homeostasis, as well as in diseases such as cancer.
PY - 2020
SP - 279
EP - 293
T2 - Nature Reviews. Immunology
TI - Organoids in immunological research
VL - 20
SN - 1474-1741
ER -