TY - JOUR
KW - Adult Stem Cells
KW - Animals
KW - Cell Lineage
KW - Cell Plasticity
KW - Cell Self Renewal
KW - Drug Resistance, Neoplasm
KW - Epithelial-Mesenchymal Transition
KW - Humans
KW - Neoplasms
KW - Neoplastic Stem Cells
KW - Stem cells
KW - Tumor Microenvironment
AU - Eduard Batlle
AU - Hans Clevers
AB - The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated stem cells. It has gradually become clear that many tumors harbor CSCs in dedicated niches, and yet their identification and eradication has not been as obvious as was initially hoped. Recently developed lineage-tracing and cell-ablation strategies have provided insights into CSC plasticity, quiescence, renewal, and therapeutic response. Here we discuss new developments in the CSC field in relationship to changing insights into how normal stem cells maintain healthy tissues. Expectations in the field have become more realistic, and now, the first successes of therapies based on the CSC concept are emerging.
BT - Nature Medicine
DA - 2017-10-06
DO - 10.1038/nm.4409
IS - 10
LA - eng
N2 - The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated stem cells. It has gradually become clear that many tumors harbor CSCs in dedicated niches, and yet their identification and eradication has not been as obvious as was initially hoped. Recently developed lineage-tracing and cell-ablation strategies have provided insights into CSC plasticity, quiescence, renewal, and therapeutic response. Here we discuss new developments in the CSC field in relationship to changing insights into how normal stem cells maintain healthy tissues. Expectations in the field have become more realistic, and now, the first successes of therapies based on the CSC concept are emerging.
PY - 2017
SP - 1124
EP - 1134
T2 - Nature Medicine
TI - Cancer stem cells revisited
VL - 23
SN - 1546-170X
ER -