TY - JOUR
KW - Animals
KW - Humans
KW - Models, Biological
KW - Organ Specificity
KW - organoids
KW - Sequence Analysis, RNA
KW - Single-Cell Analysis
KW - Stem cells
AU - Hans Clevers
AB - Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key structural and functional properties of organs such as kidney, lung, gut, brain and retina. Organoid technology can therefore be used to model human organ development and various human pathologies 'in a dish." Additionally, patient-derived organoids hold promise to predict drug response in a personalized fashion. Organoids open up new avenues for regenerative medicine and, in combination with editing technology, for gene therapy. The many potential applications of this technology are only beginning to be explored.
BT - Cell
DA - 2016-06-16
DO - 10.1016/j.cell.2016.05.082
IS - 7
LA - eng
N2 - Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key structural and functional properties of organs such as kidney, lung, gut, brain and retina. Organoid technology can therefore be used to model human organ development and various human pathologies 'in a dish." Additionally, patient-derived organoids hold promise to predict drug response in a personalized fashion. Organoids open up new avenues for regenerative medicine and, in combination with editing technology, for gene therapy. The many potential applications of this technology are only beginning to be explored.
PY - 2016
SP - 1586
EP - 1597
T2 - Cell
TI - Modeling Development and Disease with Organoids
VL - 165
SN - 1097-4172
ER -