TY - JOUR
KW - Animals
KW - Humans
KW - Immune System
KW - Lab-On-A-Chip Devices
AU - Alessandro Polini
AU - Loretta L. Del Mercato
AU - Adriano Barra
AU - Yu Shrike Zhang
AU - Franco Calabi
AU - Giuseppe Gigli
AB - Organ-on-a-chip (OoCs) platforms could revolutionize drug discovery and might ultimately become essential tools for precision therapy. Although many single-organ and interconnected systems have been described, the immune system has been comparatively neglected, despite its pervasive role in the body and the trend towards newer therapeutic products (i.e., complex biologics, nanoparticles, immune checkpoint inhibitors, and engineered T cells) that often cause, or are based on, immune reactions. In this review, we recapitulate some distinctive features of the immune system before reviewing microfluidic devices that mimic lymphoid organs or other organs and/or tissues with an integrated immune system component.
BT - Drug Discovery Today
DA - 2019-02
DO - 10.1016/j.drudis.2018.10.003
IS - 2
LA - eng
N2 - Organ-on-a-chip (OoCs) platforms could revolutionize drug discovery and might ultimately become essential tools for precision therapy. Although many single-organ and interconnected systems have been described, the immune system has been comparatively neglected, despite its pervasive role in the body and the trend towards newer therapeutic products (i.e., complex biologics, nanoparticles, immune checkpoint inhibitors, and engineered T cells) that often cause, or are based on, immune reactions. In this review, we recapitulate some distinctive features of the immune system before reviewing microfluidic devices that mimic lymphoid organs or other organs and/or tissues with an integrated immune system component.
PY - 2019
SP - 517
EP - 525
T2 - Drug Discovery Today
TI - Towards the development of human immune-system-on-a-chip platforms
VL - 24
SN - 1878-5832
ER -