TY - JOUR
KW - Biomedical Research
KW - Black or African American
KW - Cell Line
KW - GWAS
KW - Genetic Variation
KW - HeLa
KW - Humans
KW - Pharmacogenomic Testing
KW - Precision Medicine
KW - White People
KW - ancestry
KW - cell lines
KW - diversity
KW - Drug Discovery
KW - pharmacogenomics
KW - Precision Medicine
AU - Sophie Zaaijer
AU - Amanda Capes-Davis
AB - Human cell lines (CLs) are key assets for biomedicine but lack ancestral diversity. Here, we explore why genetic diversity among cell-based models is essential for making preclinical research more equitable and widely translatable. We lay out practical actions that can be taken to improve inclusivity in study design.
BT - Cell
DA - 2021-05-13
DO - 10.1016/j.cell.2021.03.041
IS - 10
LA - eng
N2 - Human cell lines (CLs) are key assets for biomedicine but lack ancestral diversity. Here, we explore why genetic diversity among cell-based models is essential for making preclinical research more equitable and widely translatable. We lay out practical actions that can be taken to improve inclusivity in study design.
PY - 2021
SP - 2525
EP - 2531
ST - Ancestry matters
T2 - Cell
TI - Ancestry matters: Building inclusivity into preclinical study design
VL - 184
SN - 1097-4172
ER -