TY - JOUR
AU - Hana Golding
AU - Surender Khurana
AU - Marina Zaitseva
AB - Animal models have played a pivotal role in all stages of vaccine development. Their predictive value for vaccine effectiveness depends on the pathogen, the robustness of the animal challenge model, and the correlates of protection (if known). This article will cover key questions regarding bridging animal studies to efficacy trials in humans. Examples include human papillomavirus (HPV) vaccine in which animal protection after vaccination with heterologous prototype virus-like particles (VLPs) predicted successful efficacy trials in humans, and a recent approval of anthrax vaccine in accordance with the “Animal Rule.” The establishment of animal models predictive of vaccine effectiveness in humans has been fraught with difficulties with low success rate to date. Challenges facing the use of animal models for vaccine development against Ebola and HIV will be discussed.
BT - Cold Spring Harbor Perspectives in Biology
DA - 2018
DO - 10.1101/cshperspect.a028902
IS - 4
LA - en
N2 - Animal models have played a pivotal role in all stages of vaccine development. Their predictive value for vaccine effectiveness depends on the pathogen, the robustness of the animal challenge model, and the correlates of protection (if known). This article will cover key questions regarding bridging animal studies to efficacy trials in humans. Examples include human papillomavirus (HPV) vaccine in which animal protection after vaccination with heterologous prototype virus-like particles (VLPs) predicted successful efficacy trials in humans, and a recent approval of anthrax vaccine in accordance with the “Animal Rule.” The establishment of animal models predictive of vaccine effectiveness in humans has been fraught with difficulties with low success rate to date. Challenges facing the use of animal models for vaccine development against Ebola and HIV will be discussed.
PY - 2018
EP - a028902
ST - What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans?
T2 - Cold Spring Harbor Perspectives in Biology
TI - What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? The Importance of Bridging Studies and Species-Independent Correlates of Protection
UR - http://cshperspectives.cshlp.org/content/10/4/a028902
VL - 10
Y2 - 2023-06-02
SN - , 1943-0264
ER -