TY - JOUR
KW - Molecular medicine
KW - translational research
AU - Anna Loewa
AU - James J. Feng
AU - Sarah Hedtrich
AB - Biomedical research is undergoing a paradigm shift towards approaches centred on human disease models owing to the notoriously high failure rates of the current drug development process. Major drivers for this transition are the limitations of animal models, which, despite remaining the gold standard in basic and preclinical research, suffer from interspecies differences and poor prediction of human physiological and pathological conditions. To bridge this translational gap, bioengineered human disease models with high clinical mimicry are being developed. In this Review, we discuss preclinical and clinical studies that benefited from these models, focusing on organoids, bioengineered tissue models and organs-on-chips. Furthermore, we provide a high-level design framework to facilitate clinical translation and accelerate drug development using bioengineered human disease models.
BT - Nature Reviews Bioengineering
DA - 2023-05-11
DO - 10.1038/s44222-023-00063-3
LA - en
N2 - Biomedical research is undergoing a paradigm shift towards approaches centred on human disease models owing to the notoriously high failure rates of the current drug development process. Major drivers for this transition are the limitations of animal models, which, despite remaining the gold standard in basic and preclinical research, suffer from interspecies differences and poor prediction of human physiological and pathological conditions. To bridge this translational gap, bioengineered human disease models with high clinical mimicry are being developed. In this Review, we discuss preclinical and clinical studies that benefited from these models, focusing on organoids, bioengineered tissue models and organs-on-chips. Furthermore, we provide a high-level design framework to facilitate clinical translation and accelerate drug development using bioengineered human disease models.
PY - 2023
SP - 1
EP - 15
T2 - Nature Reviews Bioengineering
TI - Human disease models in drug development
UR - https://www.nature.com/articles/s44222-023-00063-3
Y2 - 2023-05-25
SN - 2731-6092
ER -