TY - JOUR
KW - 3-D tissue models
KW - lung physiology
KW - mechanobiology
KW - microphysiological system
KW - organ chip
AU - Haiqing Bai
AU - Donald E. Ingber
AB - The intertwined relationship between structure and function has been key to understanding human organ physiology and disease pathogenesis. An organ-on-a-chip (organ chip) is a bioengineered microfluidic cell culture device lined by living cells and tissues that recapitulates organ-level functions in vitro. This is accomplished by recreating organ-specific tissue-tissue interfaces and microenvironmental biochemical and mechanical cues while providing dynamic perfusion through endothelium-lined vascular channels. In this review, we discuss how this emerging technology has contributed to the understanding of human lung structure-function relationships at the cell, tissue, and organ levels.
BT - Physiology
DA - 2022-09
DO - 10.1152/physiol.00012.2022
IS - 5
N2 - The intertwined relationship between structure and function has been key to understanding human organ physiology and disease pathogenesis. An organ-on-a-chip (organ chip) is a bioengineered microfluidic cell culture device lined by living cells and tissues that recapitulates organ-level functions in vitro. This is accomplished by recreating organ-specific tissue-tissue interfaces and microenvironmental biochemical and mechanical cues while providing dynamic perfusion through endothelium-lined vascular channels. In this review, we discuss how this emerging technology has contributed to the understanding of human lung structure-function relationships at the cell, tissue, and organ levels.
PY - 2022
SP - 242
EP - 252
T2 - Physiology
TI - What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology?
UR - https://journals.physiology.org/doi/abs/10.1152/physiol.00012.2022
VL - 37
Y2 - 2023-02-02
SN - 1548-9213
ER -