TY - JOUR
AU - Ana Uzquiano
AU - Paola Arlotta
AB - The development of the human brain occurs largely in utero over long periods of time and is thus experimentally inaccessible; therefore, tractable experimental models are needed. Human brain organoid have emerged as powerful model systems to investigate human-specific features of brain development. Focusing on the cerebral cortex, here, we discuss how brain, and more specifically cortical, organoid models have newly enabled discovery of aspects of progenitor biology and cortical-cell diversification that are unique to humans. We foresee that as advancements in organoid generation increase the complexity of these models, more complete replicas of the brain will empower future studies investigating higher-order aspects of brain biology, toward an understanding of the unique processing capabilities of the human brain.
BT - Current Opinion in Genetics & Development
DA - 2022-08-01
DO - 10.1016/j.gde.2022.101955
LA - en
N2 - The development of the human brain occurs largely in utero over long periods of time and is thus experimentally inaccessible; therefore, tractable experimental models are needed. Human brain organoid have emerged as powerful model systems to investigate human-specific features of brain development. Focusing on the cerebral cortex, here, we discuss how brain, and more specifically cortical, organoid models have newly enabled discovery of aspects of progenitor biology and cortical-cell diversification that are unique to humans. We foresee that as advancements in organoid generation increase the complexity of these models, more complete replicas of the brain will empower future studies investigating higher-order aspects of brain biology, toward an understanding of the unique processing capabilities of the human brain.
PY - 2022
EP - 101955
ST - Brain organoids
T2 - Current Opinion in Genetics & Development
TI - Brain organoids: the quest to decipher human-specific features of brain development
UR - https://www.sciencedirect.com/science/article/pii/S0959437X22000648
VL - 75
Y2 - 2023-02-02
SN - 0959-437X
ER -