02399nas a2200361   4500000000100000000000100001008004100002260001500043653001100058653003100069653002200100653001100122653002600133653002200159653001800181653001800199653001400217653001700231653003100248653001100279653001700290100001600307700001200323700001700335700001500352700001500367700001700382245009300399300000800492490000700500520151600507022001402023       2023                            d  c2023-12-1910aFemale10aFemale reproductive system10aGenitalia, Female10aHumans10aLab-On-A-Chip Devices10aMicrofluidic chip10amicrofluidics10aorgan-on-chip10aPregnancy10aReproduction10aUterine Cervical Neoplasms10aUterus10aWomen health1 aJinfeng Yan1 aTong Wu1 aJinjin Zhang1 aYueyue Gao1 aJia-Min Wu1 aShixuan Wang00aRevolutionizing the female reproductive system research using microfluidic chip platform  a4900 v213 aComprehensively understanding the female reproductive system is crucial for safeguarding fertility and preventing diseases concerning women's health. With the capacity to simulate the intricate physio- and patho-conditions, and provide diagnostic platforms, microfluidic chips have fundamentally transformed the knowledge and management of female reproductive health, which will ultimately promote the development of more effective assisted reproductive technologies, treatments, and drug screening approaches. This review elucidates diverse microfluidic systems in mimicking the ovary, fallopian tube, uterus, placenta and cervix, and we delve into the culture of follicles and oocytes, gametes' manipulation, cryopreservation, and permeability especially. We investigate the role of microfluidics in endometriosis and hysteromyoma, and explore their applications in ovarian cancer, endometrial cancer and cervical cancer. At last, the current status of assisted reproductive technology and integrated microfluidic devices are introduced briefly. Through delineating the multifarious advantages and challenges of the microfluidic technology, we chart a definitive course for future research in the woman health field. As the microfluidic technology continues to evolve and advance, it holds great promise for revolutionizing the diagnosis and treatment of female reproductive health issues, thus propelling us into a future where we can ultimately optimize the overall wellbeing and health of women everywhere.  a1477-3155