02273nas a2200277   4500000000100000008004100001260001500042653002300057653002000080653002000100653002300120653002500143100002200168700001400190700002100204700001900225700001900244700002000263700002300283700001900306245005900325856007200384300001100456520151400467022001401981       2025                            d  c2025-03-2110aEthical principles10aOne Health lens10aprojector model10aregulatory context10arisk decision-making1 aYadvinder Bhuller1 aMarc Avey1 aRaywat Deonandan1 aThomas Hartung1 aGina M. Hilton1 aRobin J. Marles1 aStefania Trombetti1 aDaniel Krewski00aEthical principles for regulatory risk decision-making  uhttps://www.sciencedirect.com/science/article/pii/S0273230025000431  a1058133 aRisk assessors, managers, and decision-makers are responsible for evaluating diverse human, environmental, and animal health risks. Although the critical elements of risk assessment and management are well-described in national and international documents, the ethical issues involved in risk decision-making have received comparatively little attention to date. To address this aspect, this article elaborates fundamental ethical principles designed to support fair, balanced, and equitable risk-based decision-making practices. Experts and global thinkers in risk, health, regulatory, and animal sciences were convened to share their lived experiences in relation to the intersection between risk science and analysis, regulatory science, and public health. Through a participatory and knowledge translation approach, an integrated risk decision-making model, with ethical principles and considerations, was developed and applied using diverse, contemporary risk decision-making and regulatory contexts. The ten principles - autonomy, minimize harm, maintain respect and trust, adaptability, reduce disparities, holistic, fair and just, open and transparent, stakeholder engagement, and One Health lens - demonstrate how public sector values and moral norms (i.e., ethics) are relevant to risk decision-making. We also hope these principles and considerations stimulate further discussion, debate, and an increased awareness of the application of ethics in identifying, assessing, and managing health risks.  a0273-2300