02044nas a2200781   4500000000100000000000100001008004100002260001500043653002100058653001700079653002700096653002900123653001700152653002400169100001800193700001500211700001200226700001800238700001500256700001300271700002000284700002100304700002200325700001800347700001600365700001500381700001300396700001700409700002000426700001800446700001600464700001800480700001500498700002100513700001700534700001400551700001400565700001400579700001700593700001100610700001500621700001500636700001300651700001200664700001400676700002100690700001900711700002100730700001900751700001700770700002100787700001900808700001600827700001600843700001500859700001800874700002200892700002500914700002000939700002600959700001400985700001600999700001301015245013201028856007101160490000601231022002501237       2025                            d  c2025-02-1110abrain metastasis10aglioblastoma10apatient tumor organoid10apredictive patient model10atemozolomide10atumor heterogeneity1 aTianping Peng1 aXiujian Ma1 aWei Hua1 aChangwen Wang1 aYoujun Chu1 aMeng Sun1 aValentina Fermi1 aStefan Hamelmann1 aKatharina Lindner1 aChunxuan Shao1 aJulia Zaman1 aWeili Tian1 aYue Zhuo1 aYassin Harim1 aNadja Stöffler1 aLinda Hammann1 aQungen Xiao1 aXiaoliang Jin1 aRolf Warta1 aCatharina Lotsch1 aXuran Zhuang1 aYuan Feng1 aMinjie Fu1 aXin Zhang1 aJinsen Zhang1 aHao Xu1 aFufang Qiu1 aLiqian Xie1 aYi Zhang1 aWei Zhu1 aZunguo Du1 aLorena Salgueiro1 aMark Schneider1 aFlorian Eichhorn1 aArthur Lefevre1 aStefan Pusch1 aValery Grinevich1 aMiriam Ratliff1 aSonja Loges1 aLukas Bunse1 aFelix Sahm1 aYangfei Xiang1 aAndreas Unterberg1 aAndreas von Deimling1 aMichael Platten1 aChristel Herold-Mende1 aYonghe Wu1 aHai-Kun Liu1 aYing Mao00aIndividualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy  uhttps://www.cell.com/cell-stem-cell/abstract/S1934-5909(25)00002-50 v0  a1934-5909, 1875-9777