01590nas a2200181   4500000000100000008004100001260001400042100001600056700001800072700001500090700001700105245008800122856005800210300000800268490000700276520111100283022001401394       2020                            d  c2020-9-161 aMihyeon Bae1 aHee-Gyeong Yi1 aJinah Jang1 aDong-Woo Cho00aMicrophysiological Systems for Neurodegenerative Diseases in Central Nervous System  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570039/  a8550 v113 aNeurodegenerative diseases are among the most severe problems in aging societies. Various conventional experimental models, including 2D and animal models, have been used to investigate the pathogenesis of (and therapeutic mechanisms for) neurodegenerative diseases. However, the physiological gap between humans and the current models remains a hurdle to determining the complexity of an irreversible dysfunction in a neurodegenerative disease. Therefore, preclinical research requires advanced experimental models, i.e., those more physiologically relevant to the native nervous system, to bridge the gap between preclinical stages and patients. The neural microphysiological system (neural MPS) has emerged as an approach to summarizing the anatomical, biochemical, and pathological physiology of the nervous system for investigation of neurodegenerative diseases. This review introduces the components (such as cells and materials) and fabrication methods for designing a neural MPS. Moreover, the review discusses future perspectives for improving the physiological relevance to native neural systems.  a2072-666X