01238nas a2200277   4500000000100000000000100001008004100002260001500043653002700058653003000085653001800115653002800133653002300161100002300184700002100207700002000228700001800248700001900266700001800285245006800303856005500371300000900426490000700435520050400442022001400946       2024                            d  c2024-02-2810aBiomedical Engineering10aHigh-throughput screening10areprogramming10aStem-cell biotechnology10aTissue engineering1 aPatricia R. Pitrez1 aLuis M. Monteiro1 aOliver Borgogno1 aXavier Nissan1 aJerome Mertens1 aLino Ferreira00aCellular reprogramming as a tool to model human aging in a dish  uhttps://www.nature.com/articles/s41467-024-46004-5  a18160 v153 aThe design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.  a2041-1723