01842nas a2200289   4500000000100000000000100001008004100002260001500043653001400058653001100072653002200083653000800105100001600113700002200129700001800151700001700169700002000186700002000206700001800226700002300244245005400267856005500321300000900376490000700385520114600392022001401538       2024                            d  c2024-11-2010aDatabases10aethics10aGenetic databases10aLaw1 aEmily Kirby1 aAlexander Bernier1 aRoderic Guigo1 aBarbara Wold1 aFabiana Arzuaga1 aMayumi Kusunose1 aMa’n Zawati1 aBartha M. Knoppers00aData sharing ethics toolkit: The Human Cell Atlas  uhttps://www.nature.com/articles/s41467-024-54300-3  a99010 v153 aStriving to build an exhaustive guidebook of the types and properties of human cells, the Human Cell Atlas’ (HCA) success relies on the sampling of diverse populations, developmental stages, and tissue types. Its open science philosophy preconizes the rapid, seamless sharing of data – as openly as possible. In light of the scope and ambition of such an international initiative, the HCA Ethics Working Group (EWG) has been working to build a solid foundation to address the complexities of data collection and sharing as part of Atlas development. Indeed, a particular challenge of the HCA is the diversity of sampling scenarios (e.g., living participants, deceased donors, pediatric populations, culturally diverse backgrounds, tissues from various developmental stages, etc.), and associated ethical and legal norms, which vary across countries contributing to the effort. Hence, to the extent possible, the EWG set out to provide harmonised, international and interoperable policies and tools, to guide its research community. This paper provides a high-level overview of the types of challenges and approaches proposed by the EWG.  a2041-1723