01785nas a2200349   4500000000100000000000100001008004100002260001200043653002700055653003100082653003500113653003100148653002700179100002000206700002200226700001700248700001800265700002100283700001700304700002200321700002300343700001900366700002300385700002200408700001900430245007400449856005500523300001400578490000700592520082200599022001401421       2024                            d  c2024-1110aCognitive neuroscience10aComputational neuroscience10aDiseases of the nervous system10aMagnetic Resonance Imaging10atranslational research1 aNicolas Boulant1 aFranck Mauconduit1 aVincent Gras1 aAlexis Amadon1 aCaroline Le Ster1 aMichel Luong1 aAurélien Massire1 aChristophe Pallier1 aLaure Sabatier1 aMichel Bottlaender1 aAlexandre Vignaud1 aDenis Le Bihan00aIn vivo imaging of the human brain with the Iseult 11.7-T MRI scanner  uhttps://www.nature.com/articles/s41592-024-02472-7  a2013-20160 v213 aThe understanding of the human brain is one of the main scientific challenges of the twenty-first century. In the early 2000s, the French Atomic Energy Commission launched a program to conceive and build a human magnetic resonance imaging scanner operating at 11.7 T. We have now acquired human brain images in vivo at such a magnetic field. We deployed parallel transmission tools to mitigate the radiofrequency field inhomogeneity problem and tame the specific absorption rate. The safety of human imaging at such high field strength was demonstrated using physiological, vestibular, behavioral and genotoxicity measurements on the imaged volunteers. Our technology yields T2 and T2*-weighted images reaching mesoscale resolutions within short acquisition times and with a high signal and contrast-to-noise ratio.  a1548-7105