01553nas a2200277   4500000000100000000000100001008004100002260001500043653001000058653001700068100002000085700002200105700001900127700002100146700002000167700002500187700002200212700001600234700002600250700002000276245007400296856005500370300000800425520082800433022001401261       2024                            d  c2024-09-1610aBrain10aNeuroscience1 aLaura Pritschet1 aCaitlin M. Taylor1 aDaniela Cossio1 aJoshua Faskowitz1 aTyler Santander1 aDaniel A. Handwerker1 aHannah Grotzinger1 aEvan Layher1 aElizabeth R. Chrastil1 aEmily G. Jacobs00aNeuroanatomical changes observed over the course of a human pregnancy  uhttps://www.nature.com/articles/s41593-024-01741-0  a1-83 aPregnancy is a period of profound hormonal and physiological changes experienced by millions of women annually, yet the neural changes unfolding in the maternal brain throughout gestation are not well studied in humans. Leveraging precision imaging, we mapped neuroanatomical changes in an individual from preconception through 2 years postpartum. Pronounced decreases in gray matter volume and cortical thickness were evident across the brain, standing in contrast to increases in white matter microstructural integrity, ventricle volume and cerebrospinal fluid, with few regions untouched by the transition to motherhood. This dataset serves as a comprehensive map of the human brain across gestation, providing an open-access resource for the brain imaging community to further explore and understand the maternal brain.  a1546-1726