02457nas a2200385   4500000000100000000000100001008004100002260004300043100001800086700001800104700002200122700001900144700001600163700001800179700002000197700002200217700001900239700002500258700002100283700002100304700002200325700001800347700001600365700002400381700002500405700002200430700002000452700001900472700002100491700001700512245004900529856007000578520140900648022001402057       2024                            d  c2024/03/12bEuropean UnionaLuxembourg1 aValerie Zuang1 aJoão Barroso1 aElisabet Berggren1 aStephanie Bopp1 aSara Bridio1 aSilvia Casati1 aRaffaella Corvi1 aPierre Deceuninck1 aAntonio Franco1 aAnnalisa Gastaldello1 aIngrid Langezaal1 aJulia Malinowska1 aMilena Mennecozzi1 aAnne Milcamps1 aSharon Munn1 aMonica Piergiovanni1 aPilar Prieto-Peraita1 aStavroula Sampani1 aDebora Valsesia1 aMaurice Whelan1 aClemens Wittwehr1 aAndrew Worth00aNon-Animal Methods in Science and Regulation  uhttps://publications.jrc.ec.europa.eu/repository/handle/JRC1364603 aThe 2023 EURL ECVAM Status Report outlines research and development activities, along with initiatives that foster the implementation and utilisation of non-animal methods and approaches in scientific research and regulation. The Three Rs principle, which advocates for Replacement, Reduction, and Refinement of animal use in basic, applied, and translational research, as well as for regulatory purposes, is firmly established in EU legislation, with the ultimate goal of fully replacing animal testing.
New approach methodologies encompassing a range of innovative technologies, including in vitro methods employing 3D tissues and cells, organ-on-chip technologies, computational models (including machine learning and artificial intelligence), and 'omics (transcriptomics and metabolomics), are developed, evaluated, and integrated into assessment frameworks in order to enhance the efficiency and effectiveness of hazard and risk assessment of chemicals and products across various regulatory contexts. Furthermore, substantial efforts are directed at promoting the development and utilisation of non-animal approaches in fundamental and applied research, where the majority of animal testing occurs, as well as for educational purposes. The achievements and accomplishments documented in this report are the culmination of collaborative efforts with EURL ECVAM's dedicated partners and stakeholders.  aJRC136460