01344nas a2200205   4500000000100000008004100001260001200042100001700054700001400071700001400085700001700099700001700116700001500133700001900148245006200167856006300229300001400292490000700306520082500313       2023                            d  c2023-121 aAmid Shakeri1 aYing Wang1 aYimu Zhao1 aShira Landau1 aKevin Perera1 aJonguk Lee1 aMilica Radisic00aEngineering Organ-on-a-Chip Systems for Vascular Diseases  uhttps://www.ahajournals.org/doi/10.1161/ATVBAHA.123.318233  a2241-22550 v433 aVascular diseases, such as atherosclerosis and thrombosis, are major causes of morbidity and mortality worldwide. Traditional in vitro models for studying vascular diseases have limitations, as they do not fully recapitulate the complexity of the in vivo microenvironment. Organ-on-a-chip systems have emerged as a promising approach for modeling vascular diseases by incorporating multiple cell types, mechanical and biochemical cues, and fluid flow in a microscale platform. This review provides an overview of recent advancements in engineering organ-on-a-chip systems for modeling vascular diseases, including the use of microfluidic channels, ECM (extracellular matrix) scaffolds, and patient-specific cells. We also discuss the limitations and future perspectives of organ-on-a-chip for modeling vascular diseases.