01045nas a2200325   4500000000100000000000100001008003900002260001700041653001800058653002900076653001900105653002000124653002000144653001700164653002300181653002300204100002500227700002100252700001800273700002400291700001700315700002300332700002300355245006400378856008300442300001300525490000600538520016100544022001400705       0                             d  cMar 30, 201010aanimal models10aAnimal models of disease10aanimal studies10aclinical trials10aIschemic Stroke10aMetaanalysis10aPublication ethics10aSystematic reviews1 aH. Bart van der Worp1 aDavid W. Howells1 aEmily S. Sena1 aMichelle J. Porritt1 aSarah Rewell1 aVictoria O'Collins1 aMalcolm R. Macleod00aCan Animal Models of Disease Reliably Inform Human Studies?  uhttps://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000245  ae10002450 v73 aH. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials.  a1549-1676