01343nas a2200337   4500000000100000008004100001260001500042653001800057653002600075653001800101653002300119653001100142100002100153700002200174700001900196700001800215700002000233700002300253700002000276700002500296700002000321700001500341700002200356700002300378245007400401856004700475300000700522490000700529520045500536022001400991       2021                            d  c2021-12-1410aBBB-on-a-chip10aBlood–brain barrier10amicrofluidics10aNeurovascular unit10aStroke1 aNienke R. Wevers1 aArya Lekshmi Nair1 aTania M. Fowke1 aMaria Pontier1 aDhanesh G. Kasi1 aXandor M. Spijkers1 aCharlie Hallard1 aGwenaëlle Rabussier1 aRemko van Vught1 aPaul Vulto1 aHelga E. de Vries1 aHenriëtte L. Lanz00aModeling ischemic stroke in a triculture neurovascular unit on-a-chip  uhttps://doi.org/10.1186/s12987-021-00294-9  a590 v183 aIn ischemic stroke, the function of the cerebral vasculature is impaired. This vascular structure is formed by the so-called neurovascular unit (NVU). A better understanding of the mechanisms involved in NVU dysfunction and recovery may lead to new insights for the development of highly sought therapeutic approaches. To date, there remains an unmet need for complex human in vitro models of the NVU to study ischemic events seen in the human brain.  a2045-8118