01589nas a2200385   4500000000100000008004100001260001500042100002000057700001600077700001700093700002200110700001700132700001800149700002100167700001600188700002600204700001700230700002200247700001700269700002000286700002000306700001700326700001700343700002700360700002400387700002400411700002500435700002200460245015000482856004700632300000700679490000700686520049600693022001401189       2024                            d  c2024-05-251 aEric Courchesne1 aVani Taluja1 aSanaz Nazari1 aCaitlin M. Aamodt1 aKaren Pierce1 aKuaikuai Duan1 aSunny Stophaeros1 aLinda Lopez1 aCynthia Carter Barnes1 aJaden Troxel1 aKathleen Campbell1 aTianyun Wang1 aKendra Hoekzema1 aEvan E. Eichler1 aJoao V. Nani1 aWirla Pontes1 aSandra Sanchez Sanchez1 aMichael V. Lombardo1 aJanaina S. de Souza1 aMirian A. F. Hayashi1 aAlysson R. Muotri00aEmbryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms  uhttps://doi.org/10.1186/s13229-024-00602-8  a220 v153 aSocial affective and communication symptoms are central to autism spectrum disorder (ASD), yet their severity differs across toddlers: Some toddlers with ASD display improving abilities across early ages and develop good social and language skills, while others with “profound” autism have persistently low social, language and cognitive skills and require lifelong care. The biological origins of these opposite ASD social severity subtypes and developmental trajectories are not known.  a2040-2392