01801nas a2200313   4500000000100000000000100001008004100002260001100043653001900054653002300073653002500096653002700121653001200148100002200160700001500182700002100197700001700218700002500235700002700260700003300287700002200320700001900342245007700361856004500438300000900483490000700492520097400499022001401473       2023                            d  c2023/410achronic wounds10ahypertrophic scars10ain vitro skin models10ain vitro wound healing10akeloids1 aElisabeth Hofmann1 aJulia Fink1 aAnna-Lisa Pignet1 aAnna Schwarz1 aMarlies Schellnegger1 aSebastian P. Nischwitz1 aJudith C. J. Holzer-Geissler1 aLars-Peter Kamolz1 aPetra Kotzbeck00aHuman In Vitro Skin Models for Wound Healing and Wound Healing Disorders  uhttps://www.mdpi.com/2227-9059/11/4/1056  a10560 v113 aSkin wound healing is essential to health and survival. Consequently, high amounts of research effort have been put into investigating the cellular and molecular components involved in the wound healing process. The use of animal experiments has contributed greatly to the knowledge of wound healing, skin diseases, and the exploration of treatment options. However, in addition to ethical concerns, anatomical and physiological inter-species differences often influence the translatability of animal-based studies. Human in vitro skin models, which include essential cellular and structural components for wound healing analyses, would improve the translatability of results and reduce animal experiments during the preclinical evaluation of novel therapy approaches. In this review, we summarize in vitro approaches, which are used to study wound healing as well as wound healing-pathologies such as chronic wounds, keloids, and hypertrophic scars in a human setting.  a2227-9059