03601nas a2200517   4500000000100000000000100001008004100002260001500043653002400058653001800082653002000100653002000120653001200140653002900152653001100181653003800192100002500230700002000255700002200275700002300297700002300320700001500343700002600358700002600384700002500410700001900435700002200454700001500476700002800491700001400519700001900533700001700552700003000569700002200599700002500621700002200646700002100668700002000689700002300709245015800732856009600890300001200986490000700998520206401005022001403069       2024                            d  c2024-07-2210aBiomedical Research10aPublic Health10aSocietal impact10aTranslatability10aFunding10apatient-centric research10apolicy10aresearch innovative methodologies1 aFrancesca Pistollato1 aGregor Burkhart1 aPierre Deceuninck1 aCamilla Bernasconi1 aSergio Di Virgilio1 aLuca Emili1 aAnne-Charlotte Fauvel1 aLuisa Ferreira Bastos1 aAnnalisa Gastaldello1 aChiara Gerardi1 aJens K. Habermann1 aIoan Hanes1 aChristina Kyriakopoulou1 aUma Lanka1 aPaolo Lauriola1 aHugh Laverty1 aBenoît G. C. Maisonneuve1 aMilena Mennecozzi1 aFrancesco Pappalardo1 aRoberta Pastorino1 aVilma Radvilaite1 aErwin L. Roggen1 aHelder Constantino00aWhat public health challenges and unmet medical needs would benefit from interdisciplinary collaboration in the EU? A survey and multi-stakeholder debate  uhttps://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1417684/full  a14176840 v123 a<p>In the past decade, significant European calls for research proposals have supported translational collaborative research on non-communicable and infectious diseases within the biomedical life sciences by bringing together interdisciplinary and multinational consortia. This research has advanced our understanding of disease pathophysiology, marking considerable scientific progress. Yet, it is crucial to retrospectively evaluate these efforts’ societal impact. Research proposals should be thoughtfully designed to ensure that the research findings can be effectively translated into actionable policies. In addition, the choice of scientific methods plays a pivotal role in shaping the societal impact of research discoveries. Understanding the factors responsible for current unmet public health issues and medical needs is crucial for crafting innovative strategies for research policy interventions. A multistakeholder survey and a roundtable helped identify potential needs for consideration in the EU research and policy agenda. Based on survey findings, mental health disorders, metabolic syndrome, cancer, antimicrobial resistance, environmental pollution, and cardiovascular diseases were considered the public health challenges deserving prioritisation. In addition, early diagnosis, primary prevention, the impact of environmental pollution on disease onset and personalised medicine approaches were the most selected unmet medical needs. Survey findings enabled the formulation of some research-policies interventions (RPIs), which were further discussed during a multistakeholder online roundtable. The discussion underscored recent EU-level activities aligned with the survey-derived RPIs and facilitated an exchange of perspectives on public health and biomedical research topics ripe for interdisciplinary collaboration and warranting attention within the EU’s research and policy agenda. Actionable recommendations aimed at facilitating the translation of knowledge into transformative, science-based policies are also provided.</p>  a2296-2565