01422nas a2200289   4500000000100000000000100001008004100002260001200043653002600055653001100081653001400092653001000106653000900116653002400125653003100149653002000180653001000200653001300210100001500223700001900238700001900257245008700276300001100363490000900374520073500383022001401118       2023                            d  c2023-0810aCommunicable Diseases10aHumans10ainfection10aLiver10aLung10aMicrofluidic device10amicrophysiological systems10aorgan-on-a-chip10avirus10abacteria1 aFuki Yokoi1 aSayaka Deguchi1 aKazuo Takayama00aOrgan-on-a-chip models for elucidating the cellular biology of infectious diseases  a1195040 v18703 aInfectious diseases are caused by the invasion of pathogens into a host. To explore the mechanisms of pathogen infections and cellular responses, human models that can accurately recapitulate human pathophysiology are needed. Organ-on-a-chip is a type of advanced in vitro model system that cultures cells in microfluidic devices to replicate physiologically relevant microenvironments such as 3D structures, shear stress, and mechanical stimulation. Recently, organ-on-a-chips have been widely adopted to examine the pathophysiology of infectious diseases in detail. Here, we will summarize recent advances in infectious disease research of visceral organs such as the lung, intestine, liver, and kidneys, using organ-on-a-chips.  a1879-2596