01476nas a2200241   4500000000100000000000100001008004100002260001500043653003300058653000900091653002500100653002200125653001700147653001600164653002400180653002000204653001100224653001700235100002800252245007700280856004600357520083100403       2023                            d  c2023-06-2110aMedicine and Health Sciences10abias10abiomedical research.10ain vitro research10aopen science10areliability10areporting standards10areproducibility10arigour10atransparency1 aThe RIVER working group00aReporting In Vitro Experiments Responsibly – the RIVER Recommendations  uhttps://osf.io/preprints/metaarxiv/x6aut/3 aPublications reporting in vitro experiments often lack basic details that prevent readers from repeating the experiments described or assessing whether the results are reliable. This prevents the experiments adding to the knowledge base and can lead to unnecessary subsequent studies. To address this, an international working group has been convened to develop reporting standards, drawing from its expertise in research funding and publishing, methodology and statistics, and research in academic, regulatory and industry settings. Here we present RIVER (Reporting In Vitro Experiments Responsibly), a set of six recommendations specifically tailored to reporting in vitro studies such that manuscripts describe the minimum information necessary for a reader to assess the methodological rigour and reliability of the study.