03156nas a2200313   4500000000100000000000100001008003900002260001700041653001200058653000900070653001800079653002100097653003300118653002500151653002000176653002000196100001700216700002100233700001500254700001600269700002700285700002400312245017700336856007800513300001300591490000700604520221700611022001402828       0                             d  cApr 16, 202410aFatigue10aJobs10aLabor studies10aMaterial fatigue10aMental health and psychiatry10aPsychological stress10aQuality of life10aSurvey research1 aLauren Young1 aFabienne Ferrara1 aLisa Kelly1 aTara Martin1 aSally Thompson-Iritani1 aMegan R. LaFollette00aProfessional quality of life in animal research personnel is linked to retention & job satisfaction: A mixed-methods cross-sectional survey on compassion fatigue in the USA  uhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0298744  ae02987440 v193 aBackground Working with research animals can be both rewarding and challenging. The rewarding part of the work is associated with understanding the necessity for animal research to improve the health of humans and animals and the knowledge that one can provide care and compassion for the animals. Challenges with animal research include witnessing stress/pain in animals necessitated by scientific requirements, end of study euthanasia, and societal stigmatization about animal research. These challenges could be compounded with more general workplace stresses, in turn, impacting job retention and satisfaction. However, these factors have yet to be formally evaluated. Therefore, the purpose of this survey was to comprehensively evaluate professional quality of life’s correlation with key workplace metrics. Methods Six institutions were recruited to participate in a longitudinal intervention trial on compassion fatigue resiliency. This manuscript reports key baseline metrics from this survey. A cross-sectional mixed methods survey was developed to evaluate professional quality of life, job satisfaction, retention, and factors influencing compassion fatigue resiliency. Quantitative data were analyzed via general linear models and qualitative data were analyzed by theme. Results Baseline data was collected from 198 participants. Personnel who reported higher compassion satisfaction also reported higher retention and job satisfaction. Conversely, personnel who reported higher burnout also reported lower job satisfaction. In response to open-ended questions, participants said their compassion fatigue was impacted by institutional culture (70% of participants), animal research (58%), general mental health (41%), and specific compassion fatigue support (24%). Conclusions In conclusion, these results show that professional quality of life is related to important operational metrics of job satisfaction and retention. Furthermore, compassion fatigue is impacted by factors beyond working with research animals, including institutional culture and general mental health support. Overall, this project provides rationale and insight for institutional support of compassion fatigue resiliency.  a1932-6203