01552nas a2200241   4500000000100000008004100001260001500042653001800057653002400075653003200099653001100131653002900142653002200171100002300193700002500216700001600241245009900257856007200356300001100428490000700439520085000446022001401296       2024                            d  c2024-03-2110aanimal models10aBiomedical Research10ahuman-centric methodologies10apolicy10apublic health challenges10asystemic thinking1 aHelder Constantino1 aFrancesca Pistollato1 aTroy Seidle00aTransitioning biomedical research toward human-centric methodologies: systems-based strategies  uhttps://www.sciencedirect.com/science/article/pii/S1359644624000722  a1039470 v293 aHuman-centric methodologies like microphysiological systems and in silico methods have shown promise in addressing the limitations of animal models in understanding human biology and responding to public health priorities. However, the prevailing paradigm based on animal research persists. The article proposes a systemic thinking approach, endorsed by the OECD and the EU, as a tool to leverage innovation to reframe the issue and achieve transformative policies. By identifying the complex factors shaping method selection in basic and biomedical research, a simplified model is presented to illuminate the systemic nature of this decision-making process. The goal is not to prescribe solutions but to offer policymakers a new framework for more-effective strategies, emphasizing collaboration among stakeholders and the need for robust data.  a1359-6446