02559nas a2200481   4500000000100000000000100001008004100002260000900043653001100052653001100063653002000074653002500094653002500119653003100144653002200175653002000197100001900217700003000236700001900266700002800285700002000313700002100333700001800354700001900372700002000391700001500411700002100426700001500447700002200462700001500484700002000499700001800519700001700537700002600554700001600580700002300596700001800619245006300637300001200700490000700712520134400719022001402063       2022                            d  c202210aEurope10aHumans10aRisk Assessment10aenvironmental agents10aevidence integration10anew approach methodologies10apopulation health10aRisk Assessment1 aDaniel Krewski1 aPatrick Saunders-Hastings1 aRobert A. Baan1 aTara S. Barton-Maclaren1 aPatience Browne1 aWeihsueh A. Chiu1 aMaureen Gwinn1 aThomas Hartung1 aAndrew D. Kraft1 aJuleen Lam1 aR. Jeffrey Lewis1 aMoez Sanaa1 aRebecca L. Morgan1 aGreg Paoli1 aLorenz Rhomberg1 aAndrew Rooney1 aSalomon Sand1 aHolger J. Schünemann1 aKurt Straif1 aKristina A. Thayer1 aKatya Tsaioun00aDevelopment of an Evidence-Based Risk Assessment Framework  a667-6930 v393 aAssessment of potential human health risks associated with environmental and other agents requires careful evaluation of all available and relevant evidence for the agent of interest, including both data-rich and data-poor agents. With the advent of new approach methodologies in toxicological risk assessment, guidance on integrating evidence from mul-tiple evidence streams is needed to ensure that all available data is given due consideration in both qualitative and quantitative risk assessment. The present report summarizes the discussions among academic, government, and private sector participants from North America and Europe in an international workshop convened to explore the development of an evidence-based risk assessment framework, taking into account all available evidence in an appropriate manner in order to arrive at the best possible characterization of potential human health risks and associated uncertainty. Although consensus among workshop participants was not a specific goal, there was general agreement on the key consider-ations involved in evidence-based risk assessment incorporating 21st century science into human health risk assessment. These considerations have been embodied into an overarching prototype framework for evidence integration that will be explored in more depth in a follow-up meeting.  a1868-8551