01093nas a2200229   4500000000100000000000100001008004100002260001200043653001200055653002400067653001900091653003700110653001100147100001800158700002100176700001600197245005500213300001200268490000700280520056200287022001400849       2018                            d  c2018-1010aAnimals10aComputer Simulation10aDrug Discovery10aHigh-Throughput Screening Assays10aHumans1 aJanet Piñero1 aLaura I. Furlong1 aFerran Sanz00aIn silico models in drug development: where we are  a111-1210 v423 aThe use and utility of computational models in drug development has significantly grown in the last decades, fostered by the availability of high throughput datasets and new data analysis strategies. These in silico approaches are demonstrating their ability to generate reliable predictions as well as new knowledge on the mode of action of drugs and the mechanisms underlying their side effects, altogether helping to reduce the costs of drug development. The aim of this review is to provide a panorama of developments in the field in the last two years.  a1471-4973