00686nas a2200217   4500000000100000000000100001008004100002260001200043653001800055100001600073700002000089700002200109700002100131700002000152245006500172856004500237300001000282490000700292520015500299022001400454       2014                            d  c2014-0110aBiotechnology1 aMichael Hay1 aDavid W. Thomas1 aJohn L. Craighead1 aCelia Economides1 aJesse Rosenthal00aClinical development success rates for investigational drugs  uhttps://www.nature.com/articles/nbt.2786  a40-510 v323 aThe most comprehensive survey of clinical success rates across the drug industry to date shows productivity may be even lower than previous estimates.  a1546-1696