02701nas a2200301   4500000000100000000000100001008004100002260001100043653002100054653001800075653002600093653002200119100002200141700002000163700002100183700001900204700002000223700002100243700001900264700002200283700002400305245008200329856004400411300000800455490000700463520191500470022001402385       2023                            d  c2023/310a3D (bio)printing10aopportunities10aPersonalized medicine10aSystematic review1 aDobromira Shopova1 aAntoniya Yaneva1 aDesislava Bakova1 aAnna Mihaylova1 aPetya Kasnakova1 aMaria Hristozova1 aYordan Sbirkov1 aVictoria Sarafian1 aMariya Semerdzhieva00a(Bio)printing in Personalized Medicine—Opportunities and Potential Benefits  uhttps://www.mdpi.com/2306-5354/10/3/287  a2870 v103 aThe global development of technologies now enters areas related to human health, with a transition from conventional to personalized medicine that is based to a significant extent on (bio)printing. The goal of this article is to review some of the published scientific literature and to highlight the importance and potential benefits of using 3D (bio)printing techniques in contemporary personalized medicine and also to offer future perspectives in this research field. The article is prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Web of Science, PubMed, Scopus, Google Scholar, and ScienceDirect databases were used in the literature search. Six authors independently performed the search, study selection, and data extraction. This review focuses on 3D bio(printing) in personalized medicine and provides a classification of 3D bio(printing) benefits in several categories: overcoming the shortage of organs for transplantation, elimination of problems due to the difference between sexes in organ transplantation, reducing the cases of rejection of transplanted organs, enhancing the survival of patients with transplantation, drug research and development, elimination of genetic/congenital defects in tissues and organs, and surgery planning and medical training for young doctors. In particular, we highlight the benefits of each 3D bio(printing) applications included along with the associated scientific reports from recent literature. In addition, we present an overview of some of the challenges that need to be overcome in the applications of 3D bioprinting in personalized medicine. The reviewed articles lead to the conclusion that bioprinting may be adopted as a revolution in the development of personalized, medicine and it has a huge potential in the near future to become a gold standard in future healthcare in the world.  a2306-5354