01119nas a2200169   4500000000100000008004100001260001600042100001900058700002300077700002500100700002100125700002000146245007400166856005600240300001200296520064100308       2019                            d  c2019bBrill1 aJohn J. Pippin1 aSarah E. Cavanaugh1 aFrancesca Pistollato1 aKathrin Herrmann1 aKimberley Jayne00aAnimal Research for Alzheimer Disease: Failures of Science and Ethics  uhttps://www.jstor.org/stable/10.1163/j.ctvjhzq0f.27  a480-5163 aPerhaps the most impactful and foreboding development in chronic diseases in recent decades has been the increasing prevalence and awareness of dementia. The various dementias, especially Alzheimer disease (AD), have derailed and ended the lives of tens of millions in America and worldwide. It is a truism that AD patients die twice. First the mind dies, and only later does the body. AD uniquely and unremittingly affects not only patients, but their families, caregivers, and communities. In recent years, AD may have displaced cancer as the most feared disease among Americans. As with other diseases that have no meaningful methods