02172nas a2200337   4500000000100000008004100001260001500042653000800057653002200065653002500087653000900112653003500121653001200156653001300168653000900181653003300190653002500223653003100248653000800279100002400287700001900311700002000330700002000350700001800370245013800388856007200526300001100598490000800609520120300617022001401820       2023                            d  c2023-10-0110aAKT10aDisease modelling10aEmbryonic stem cells10aIGF110ainduced pluripotent stem cells10aInsulin10aMAPK-ERK10amTOR10aNeurodevelopmental disorders10aNeuronal cell models10aNeuropsychiatric disorders10aRAS1 aJános M. Réthelyi1 aKatalin Vincze1 aDorothea Schall1 aJeffrey Glennon1 aSimone Berkel00aThe role of insulin/IGF1 signalling in neurodevelopmental and neuropsychiatric disorders – Evidence from human neuronal cell models  uhttps://www.sciencedirect.com/science/article/pii/S0149763423002993  a1053300 v1533 aInsulin and insulin-like growth factor 1 (IGF1) signalling play a central role in the development and maintenance of neurons in the brain, and human neurodevelopmental as well as neuropsychiatric disorders have been linked to impaired insulin and IGF1 signalling. This review focuses on the impairments of the insulin and IGF1 signalling cascade in the context of neurodevelopmental and neuropsychiatric disorders, based on evidence from human neuronal cell models. Clear evidence was obtained for impaired insulin and IGF1 receptor downstream signalling in neurodevelopmental disorders, while the evidence for its role in neuropsychiatric disorders was less substantial. Human neuronal model systems can greatly add to our knowledge about insulin/IGF1 signalling in the brain, its role in restoring dendritic maturity, and complement results from clinical studies and animal models. Moreover, they represent a useful model for the development of new therapeutic strategies. Further research is needed to systematically investigate the exact role of the insulin/IGF1 signalling cascades in neurodevelopmental and neuropsychiatric disorders, and to elucidate the respective therapeutic implications.  a0149-7634