01406nas a2200265   4500000000100000000000100001008004100002260001500043653001100058653001900069653001300088653002100101653002300122100001400145700001500159700001600174700001600190700001400206245004500220856004700265300000700312490000700319520080000326022001401126       2023                            d  c2023-08-0310aCancer10aDrug screening10aorganoid10aOrganoid Biobank10aPrecision Medicine1 aZhen Fang1 aPeijuan Li1 aFengying Du1 aLiang Shang1 aLeping Li00aThe role of organoids in cancer research  uhttps://doi.org/10.1186/s40164-023-00433-y  a690 v123 aOrganoids are established through in vitro 3D culture, and they can mimic the structure and physiological functions of organs or tissues in vivo. Organoids have attracted much attention in recent years. They can provide a reliable technology platform for cancer research and treatment and are a valuable preclinical model for academic research and personalized medicine. A number of studies have confirmed that organoids have great application prospects in new drug development, drug screening, tumour mechanism research, and precision medicine. In this review, we mainly focus on recent advances in the application of organoids in cancer research. We also discussed the opportunities and challenges facing organoids, hoping to indicate directions for the development of organoids in the future.  a2162-3619